| 用于细胞核成像的2,7-BHVC双光子荧光探针 |
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| 引用本文： | 贾鹏飞,刘恒,张元红,刘鑫,赵宁,于晓强. 用于细胞核成像的2,7-BHVC双光子荧光探针[J]. 高等学校化学学报, 2010, 31(6): 1075-1077 |
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| 作者姓名： | 贾鹏飞 刘恒 张元红 刘鑫 赵宁 于晓强 |
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| 作者单位： | 兰州大学生命科学学院,兰州,730000;山东大学晶体材料国家重点实验室,济南,250100 |
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| 基金项目： | 国家自然科学基金,教育部博士点基金 |
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| 摘 要： | 分别合成了2,7-双(1-羟乙基-4-乙烯基吡啶) 咔唑碘盐(2,7-BHVC)与3,6-BHVC, 进行了荧光性能和细胞核成像测试, 结果表明, 2,7位的Ф×δ是3,6位的2.8~3.6倍, 染色实验也证实了2,7-BHVC有特定成像细胞核的能力.
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| 关 键 词： | 双光子荧光探针 双光子荧光成像 DNA |
| 收稿时间： | 2010-01-18 |
Novel Two-photon Fluorescent Probe 2,7-BHVC for DNA Imaging |
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| JIA Peng-Fei,LIU Heng,ZHANG Yuan-Hong,LIU Xin,ZHAO Ning,YU Xiao-Qiang. Novel Two-photon Fluorescent Probe 2,7-BHVC for DNA Imaging[J]. Chemical Research In Chinese Universities, 2010, 31(6): 1075-1077 |
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| Authors: | JIA Peng-Fei LIU Heng ZHANG Yuan-Hong LIU Xin ZHAO Ning YU Xiao-Qiang |
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| Affiliation: | 1. School of Life Science, Lanzhou University, Lanzhou 730000, China;2. State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100, China |
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| Abstract: | 2,7-BHVC,a novel two-photon fluorescent probe for DNA with large two-photon excited fluorescence action cross sections,was synthesized and characterized.It emits weak two-photon fluorescence in aqueous solution while its two-photon fluorescence is strongly restored upon binding to DNA.The two-photon imaging in cell demonstrated that 2,7-BHVC can exactly label nuclear DNA. |
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| Keywords: | DNA |
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