Facile Synthesis of Thioamides via P2S5‐Mediated Beckmann Rearrangement of Oximes |
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| Authors: | Jiangsheng Li Chao Cheng Xinrui Zhang Zhiwei Li Feifei Cai Yuan Xue Weidong Liu |
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| Affiliation: | Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation, School of Chemistry and Biological Engineering, Changsha University of Science & Technology, Changsha, Hunan 410114, China |
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| Abstract: | A facile and efficient approach to the synthesis of secondary thioamides from ketoximes via Beckmann rearrangement has been established, using phosphorus pentasulfide as a dehydrating and thiating agent. It is also efficient for the preparation of primary thiobenzamide from benzaldoxime. This approach features simple‐operation, easy‐control and good to excellent yields. |
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| Keywords: | thioamides oximes phorphorus pentasulfide Beckmann rearrangement iminocarbocation |
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