Synthesis and Antioxidant Activities of Novel 4,4′‐Arylmethylene‐bis(1H‐pyrazole‐5‐ol)s from Lignin |
| |
| Authors: | Xiaohui Yang Pinghu Zhang Yonghong Zhou Junsong Wang Hongjun Liu |
| |
| Affiliation: | 1. Institute of Chemical Industry of Forestry Products, Chinese Academy of Forestry (CAF);2. National Engineering Lab for Biomass Chemical Utilization;3. Key Laboratory of Forest Chemical Engineering, State Forestry Administration (SFA);4. Key Laboratory of Biomass Energy and Material;5. Nanjing 210042, China;6. Jiangsu Center for New Drug Screening & National Drug Screening Laboratory;7. China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China;8. Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China |
| |
| Abstract: | A series of novel bispyrazoles joined by arylmethylene at C‐4 position were synthesized with aromatic aldehydes obtained from lignin and screened for their in vitro antioxidant activities by N,N‐diphenyl‐N′‐picrylhydrazyl (DPPH) and 2,2′‐azino‐bis(3‐ethylenzothiazoline‐sulphonic acid) diammonium salt (ABTS+) radical scavenging assays. All of these compounds exhibited good DPPH and ABST+ radical scavenging activities as compared to the standard, Trolox, which suggested their potential as promising agents for curing tumors or other free radical‐related diseases. |
| |
| Keywords: | pyrazole microwave chemistry aromatic aldehyde 4,4′ ‐arylmethylene‐bis(1H‐pyrazole‐5‐ol) lignin antioxidants |
|
|
