Catalytic,Conjugate Reduction‐Aldol Addition Reaction of β′‐Oxoalkyl α,β‐Unsaturated Carboxylates |
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| Authors: | Aijun Zheng Lan Jiang Zhengning Li |
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| Affiliation: | 1. College of Environmental and Chemical Engineering, Dalian University, Dalian, Liaoning 116622, China;2. Liaoning Key Laboratory of Bioorganic Chemistry, Dalian University, Dalian, Liaoning 116622, China |
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| Abstract: | Intramolecular conjugate reduction‐aldol addition reactions of β′‐oxoalkyl α,β‐unsaturated carboxylates were performed in the presence of copper catalysts generated in situ from copper salts, phosphine ligands and silanes. Moderate to good yields and high diastereoselectivities were obtained in 15 min to 3 h using bis[(2‐diphenylphosphino)phenyl] ether as the ligand. |
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| Keywords: | conjugate reduction aldol addition domino reaction copper hydride catalysis |
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