Synthesis of 2‐Mercaptobenzaldehyde, 2‐Mercaptocyclohex‐1‐enecarboxaldehydes and 3‐Mercaptoacrylaldehydes |
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Authors: | Qingfen Niu Xiaofeng Xu Hongjian Sun Xiaoyan Li |
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Institution: | School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong 250100, China |
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Abstract: | A novel one‐pot approach for the preparation of 2‐mercaptobenzaldehyde, 2‐mercaptocyclohex‐1‐enecarboxaldehydes and 3‐mercaptoacrylaldehydes (Z)‐3‐mercapto‐2‐methyl‐3‐phenylacrylaldehyde, 3‐mercapto‐3‐(o‐tolyl)acrylaldehyde)] starting from ortho‐bromobenzaldehyde, 2‐chlorocyclohex‐1‐enecarbaldehydes, (Z)‐3‐chloro‐2‐methyl‐3‐phenylacrylaldehyde and 3‐chloro‐3‐(o‐tolyl)acrylaldehyde is reported. The reaction of sulfur with the Grignard reagent of the acetal for the protection of the aldehyde group affords the title compounds through hydrolysis with dilute hydrochloric acid in high yields. |
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Keywords: | 2‐mercaptobenzaldehyde 2‐mercaptocyclohex‐1‐enecarboxaldehydes 3‐mercaptoacrylaldehydes Grignard reagent sulfur aldehyde |
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