Novel Synthetic Route to α‐Aminophosphonates Containing Benzothiazole Moiety |
| |
| Authors: | Liju Gu Rui Wang Xiangzhong Huang Cheng Jin |
| |
| Affiliation: | 1. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming, Yunnan 650500, China;2. Changzhou Tianma Group Limited Company, Changzhou, Jiangsu 213127, China |
| |
| Abstract: | A novel and ef?cient synthetic route to α‐aminophosphonates containing benzothiazole moiety via a cascade three‐component reaction from conveniently available starting materials has been developed. The target compounds 3a – 3g , 7 and 8a , 8b were evaluated for their anticancer activities against the cancer cell line HL‐60 in vitro by the MTT method. Compound 3g showed good cancer inhibitory activity against the tested cell line. Further study is necessary to find out the potential antitumor activities. |
| |
| Keywords: | cascade three‐component reaction α ‐aminophosphonates antitumor activity |
|
|
