Studies on antibacterial agents. III. Synthesis and antibacterial activities of substituted 1,4-dihydro-8-methyl-4-oxoquinoline-3-carboxylic acids |
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Authors: | H Miyamoto H Ueda T Otsuka S Aki H Tamaoka M Tominaga K Nakagawa |
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Institution: | 2nd Tokushima Institute of New Drugs Research, Otsuka Pharmaceutical Co., Ltd., Japan. |
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Abstract: | A series of substituted 4-oxoquinoline-3-carboxylic acids having a methyl group at the 8-position was prepared and tested for their antibacterial activity. 7-(trans-3-Amino-4-methyl-1-pyrrolidinyl)-1-cyclopropyl-1,4-dihydro-6- fluoro-8-methyl-4-oxoquinoline-3-carboxylic acid (21) exhibited highly potent antibacterial activity against both gram-positive and gram-negative bacteria, including Pseudomonas aeruginosa. |
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