Lucidumol D,a new lanostane-type triterpene from fruiting bodies of Reishi (Ganoderma lingzhi) |
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| Authors: | Dedi Satria Yhiya Amen Yasuharu Niwa Ahmed Ashour Ahmed E Allam |
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| Institution: | 1. Division of Systematic Forest and Forest Products Sciences, Department of Agro-Environmental Sciences, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan;2. Faculty of Health and Sciences, Muhammadiyah University of Sumatera Barat, Bukittinggi Indonesia;3. Faculty of Pharmacy, Department of Pharmacognosy, Mansoura University, Mansoura, Egypt;4. Faculty of Pharmacy, Department of Pharmacognosy, Al-Azhar University, Assuit, Egypt |
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| Abstract: | A new lanostane-type triterpenoid, lucidumol D (1) was isolated from the fruiting bodies of Ganoderma lingzhi. Its structure was elucidated on the basis of extensive 1D- and 2D-NMR studies as well as mass spectrometry. The cytotoxicity of lucidumol D against proliferation of several cancer cells were assayed by using MTT method and the obtained result suggested selective anti-proliferative and cytotoxic effects against MCF-7, HepG2, HeLa, Caco-2, and HCT-116. In comparison to lucidumol C (2) isolated previously by our group, the structure-activity relationship indicated that carbonyl function at C-11 is necessary to enhance the cytotoxicity. |
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| Keywords: | Lucidumol D Ganoderma lingzhi triterpene cytotoxicity |
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