Heliotropium bacciferum Forssk. (Boraginaceae) extracts: chemical constituents,antioxidant activity and cytotoxic effect in human cancer cell lines |
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| Authors: | Hanane Aïssaoui Tiziana Esposito Nunziatina De Tommasi Patrizia Gazzerro Samir Benayache |
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| Affiliation: | 1. Unité de Recherche Valorisation des Ressources naturelles et Analyses physico-Chimiques et Biologiques, Université Frères Mentouri, Constantine, Algérie;2. Dipartimento di Farmacia, Universita degli Studi di Salerno, Fisciano, Italy;3. Program in Drug Discovery and Development, University of Salerno, Fisciano, Italy |
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| Abstract: | Heliotropium bacciferum (Boraginaceae) is a perennial herb, growing in the Bechar region of Algeria, where it is traditionally used for skin diseases and tonsillitis. Herein, we report the isolation and characterization of sixteen secondary metabolites from the aerial part extracts. They include a sterol (1), megastigman type nor-isoprenoids (2, 3, 4, 6, 8, 10), C-11 terpene lactones (5 and 9), and a monoterpene (7) from the chloroform extract (HB-C); monoterpene glucoside (14), and phenolic compounds (11–13, 15, 16) from the methanol one (HB-M). Their structures were elucidated by spectroscopic methods including 1D and 2D NMR experiments, and ESIMS analysis. HB-M showed a significant and concentration dependent scavenging activity in vitro against the radicals DPPH and ABTS, related to the phenol derivatives (11–13, and 15–16), and HB-C inhibited the growth of colon cancer cell lines, mainly for the presence of the antiproliferative C-11 terpene lactones (5 and 9). |
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| Keywords: | Heliotropium bacciferum Boraginaceae terpenoids polyphenols antioxidant activity cytotoxic effect |
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