New chemical constituents from the fruits of Zanthoxylum armatum and its in vitro anti-inflammatory profile |
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| Authors: | Zulfa Nooreen Anant Kumar Dnyaneshwar Umrao Bawankule Sudeep Tandon Mohd Ali Tran Dang Xuan |
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| Affiliation: | 1. Process Chemistry and Technology Department, Central Institute of Medicinal and Aromatic Plants, Lucknow, India;2. Molecular Bioprospection Department, Central Institute of Medicinal and Aromatic Plants, Lucknow, India;3. Faculty of Pharmacy, Jamia Hamdard (Hamdrad University), New Delhi, India;4. Graduate School for International Development and Cooperation, Hiroshima University, Hiroshima, Japan |
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| Abstract: | Chemical investigations on the fruits of Zanthoxylum armatum Roxb. (Rutaceae) led to the isolation of two new constituents characterised as 2α-methyl-2β-ethylene-3β-isopropyl-cyclohexan-1β, 3α-diol (1) and phenol-O-β-D-arabinopyranosyl-4′-(3″, 7″, 11″, 15″-tetramethyl)-hexadecan-1″-oate (2) along with known compounds m-methoxy palmityloxy benzene (3), acetyl phenyl acetate (4), linoleiyl-O-α-D-xylopyranoside (5), m-hydroxyphenoxy benzene (6) and palmitic acid (7). The chemical structures were established with the help of physical, chemical and spectroscopic methods. The anti-inflammatory potential of isolated compounds 1 and 2 was evaluated using in vitro target-based anti-inflammatory activity in LPS-stimulated primary peritoneal macrophages isolated from mice. Production of pro-inflammatory cytokines (TNF-α and IL-6) was significantly inhibited by the treatment of isolated compounds 1 and 2 in a dose-dependent manner. |
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| Keywords: | Zanthoxylum armatum new constituents anti-inflammatory activity |
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