Chemical constituents of Silene montbretiana |
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| Authors: | Hilal Kılınç Alfredo Bottone Tamer Karayıldırım Özgen Alankuş Sonia Piacente |
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| Affiliation: | 1. Faculty of Engineering, Department of Geological Engineering, Dokuz Eylül University, Buca, ?zmir, Turkey;2. Faculty of Science, Department of Chemistry, Ege University, Bornova, ?zmir, Turkey;3. Department of Pharmacy, University of Salerno, Fisciano, Italy;4. Faculty of Science, Department of Chemistry, Ege University, Bornova, ?zmir, Turkey!["ORCID]("//:0" "\"ORCID") https://orcid.org/0000-0001-7451-0810;5. Faculty of Science, Department of Chemistry, Ege University, Bornova, ?zmir, Turkey |
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| Abstract: | A new steroidal glycoside, 3-O-β-d-glucopyranosyl-3β,25-dihydroxy-5β-cholest-7-en-6-one 25-O-β-d-glucopyranoside (1), together with six known steroidal derivatives (2-7), one cerebroside (8) and one flavonoid (9) were isolated from Silene montbretiana Boiss (Caryophyllaceae), a perennial herb growing mainly in the Middle and East Anatolia, Azerbaijan, Iran, and Turkey. Their structures were established by the extensive use of 1D and 2D NMR experiments along with ESI-MS analyses. The cytotoxicity against the cancer A549 (human alveolar basal carcinoma) and Hela (human epitheloid cervix carcinoma) cell lines has been evaluated. None of the tested compounds, in a range of concentrations between 12.5 and 100 μM, caused a significant reduction of the cell number. |
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| Keywords: | Silene montbretiana ecdysteroid cholest-7-en-6-one derivatives MTT assay |
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!["ORCID]({"type":"image","src":"/templates/jsp/images/orcid.png"} "\"ORCID")
https://orcid.org/0000-0001-7451-0810;5. Faculty of Science, Department of Chemistry, Ege University, Bornova, ?zmir, Turkey