A new benzofuran from Artemisia halodendron Turcz. ex Bess. |
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| Authors: | Jinfeng Sun Wei Zhou Cheng-Xi Wei Zhihong Zhang Xuejun Jin |
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| Affiliation: | 1. Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, PR China;2. Medical College, Inner Mongolia University for Nationalities, Tongliao, PR China |
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| Abstract: | A new benzofuran, methyl (2S,2″S,3′E)-[2-(1″-acetoxypropan-2-yl)-2,3-dihydrobenzofuran-5-yl]acrylate (1), and 13 known compounds (2–14) were isolated from an ethanol extract of Artemisia halodendron Turcz. ex Bess. The chemical structures of these compounds were determined by 1D and 2D NMR (1H-1H COSY, HMBC, HMQC and NOESY) and HR-ESI-MS spectra, and results were compared with data from the literature. The effects of compounds 1–14 were measured on NF-κB activation, with compounds 2 and 3 exhibiting inhibitory activities against TNF-α-induced NF-κB reporter gene expression in HeLa cells from 10 to 100 μM. |
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| Keywords: | Artemisia halodendron benzofuran nuclear factor-κB (NF-κB) |
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