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Phytochemical profiles,antioxidant and anti-acetylcholinesterasic activities of the leaf extracts of Rhamnus lycioides subsp. oleoides (L.) Jahand. & Maire in different solvents
Authors:Houari Benamar  Elonge Rarivoson  Lamberto Tomassini  Claudio Frezza  Abderrazak Marouf  Malika Bennaceur
Institution:1. Department of Biology, University of Mostaganem Abdelhamid Ibn Badis, Mostaganem, Algeria;2. Department of Biology, University of Oran 1 Ahmed Benbella, Oran, Algeriahouaribenamar@hotmail.com houari.benamar@univ-mosta.dz;3. Department of Biology, University of Oran 1 Ahmed Benbella, Oran, Algeria;4. Department of Environmental Biology, University of Rome “La Sapienza”, Rome, Italy;5. Department of Natural Sciences and Life, Ctr Univ Naama, Naama, Algeria;6. Department of Biology and Physiology of Organisms, University of Science and Technology Houari Boumediene, Algiers, Algeria
Abstract:In this work, the extracts obtained with different solvents from the leaves of Rhamnus lycioides subsp. oleoides (L.) Jahand. & Maire were studied for their phytochemical profile and then for their antioxidant and acetylcholinesterase inhibitory activities. The phytochemical profiles of the extracts in n-hexane, dichloromethane, ethyl acetate, methanol, anthraquinone rich and water, showed the presence of different compounds belonging to several classes of natural products such as flavonoids, anthraquinones, saccharides and fatty acids. For what concerns the biological tests, the ethyl acetate, methanol and anthraquinone rich extracts showed the highest activities in both assays due to the high amount of compounds possessing those properties such as flavonoids and anthraquinones. By consequence, these specific extracts of the species may be considered to be potential sources of natural antioxidant and anti-acetylcholinesterasic compounds.
Keywords:Rhamnus lycioides subsp  oleoides  leaf extracts  different solvents  HPLC-UV-DAD  HPLC-API-MS  antioxidant and anti-acetylcholinesterasic activities
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