A new naphthoquinone analogue and antiviral constituents from the root of Rhinacanthus nasutus |
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Authors: | Tran Minh Ngoc Nguyen Thi Thanh Phuong Nguyen Minh Khoi SeonJu Park Hee Jae Kwak Nguyen Xuan Nhiem |
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Institution: | 1. National Institute of Medicinal Materials, Hanoi, Vietnam;2. College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Korea;3. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam |
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Abstract: | Rhinacanthus nasutus (L.) Kurz (Acanthaceae) is known as traditional medicine for the treatment of fungal and herpes virus infections. A new naphthoquinone racemate, rhinacasutone (1) together with seven known compounds, rhinacanthone (2), rhinacanthins C, D, N, Q, and E (3–7), and heliobuphthalmin (8) were isolated from root of R. nasutus. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR and MS data. All the isolated compounds were tested for their antiviral activities against PR8, HRV1B, and CVB3-infected vero cells. Compounds 3–6 exhibited significant antiviral activities with the IC50 value ranging from 0.03 to 23.7 μM in all three infections. |
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Keywords: | Rhinacasutone rhinacanthin Rhinacanthus nasutus antivirus |
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