Two new noroleanane-type triterpenoid saponins from the stems of Stauntonia chinensis |
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| Authors: | Tong-Tong Feng Yi-Sheng Yang Zhi-Qiang Zhou Mian Dai Hong-Yu Bi |
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| Institution: | 1. Jiangxi Provincial Engineering Research Center for Drug and Medical Device Quality, Jiangxi Provincial Institute for Drug Control , Nanchang, China;2. Jiangxi University of Traditional Chinese Medicine , Nanchang, China;3. Jiangxi Provincial Engineering Research Center for Drug and Medical Device Quality, Jiangxi Provincial Institute for Drug Control , Nanchang, China |
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| Abstract: | Two new noroleanane-type triterpenoid saponins, 3β,20α,24-trihydroxy-29-norolean-12-en-28-oic acid 24-O-β-L-fucopyranosyl-(1→2)-β-D-xylopyranosyl-(1→3)]-β-D-glucopyranoside (1) and 3β,20α,24-trihydroxy-29-norolean-12-en-28-oic acid 24-O-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranosyl-(1→3)]-β-D-glucopyranoside (2) were isolated from the stems of Stauntonia chinensis DC., together with three known compounds, brachyantheraoside B2 (3), eupteleasaponin Ⅷ (4) and fargoside B (5). Their structures were elucidated by spectroscopic and chemical methods. The cytotoxic activities of compounds 1 and 2 were evaluated against five human tumor cell lines (HCT-116, HepG2, BGC-823, NCI-H1650, and A2780). Compounds 1 and 2 showed moderate cytotoxic activities toward the tested cell lines with IC50 values ranging from 12.71 to 32.04 μM. |
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| Keywords: | Stauntonia chinensis Lardizabalaceae noroleanane-type triterpenoids cytotoxic activity |
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