Isochromanes from Aspergillus fumigatus,an endophytic fungus from Cordyceps sinensis |
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| Authors: | Xiao-Hua Li Xue-Hua Han Ling-Ling Qin Jun-Lin He Zhi-Xing Cao Yu-Cheng Gu |
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| Institution: | 1. The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory, Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine , Chengdu, P R China;2. Syngenta Jealott’s Hill International Research Centre , Berkshire, UK |
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| Abstract: | Four previously undescribed isochromanes were isolated from the fermentation broth of an endophytic fungus Aspergillus fumigatus, which was obtained from the fruiting body of Cordyceps sinensis. Their structures were elucidated through extensive spectroscopic analyses. One racemic isochromane was further purified by chiral HPLC to yield a pair of enantiomers and their absolute configurations were determined by quantum chemical ECD calculations. These isolated compounds were evaluated for cytotoxicity against two cell lines (MV4-11 and MDA-ME-231) and the result showed that compounds 1a and 2 exhibited moderate growth inhibition against MV4-11 cell line. |
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| Keywords: | Aspergillus fumigatus azaphilone isochromane Cordyceps sinensis cytotoxicity |
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