Senecipyrrolidine,an unusual pyrrolidine alkaloid isolated from Jacobaea gigantea (Desf.) Pelser (Asteraceae) |
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Authors: | Nadjet Mezache Hocine Laouer Pascal Richomme Denis Séraphin Salah Akkal |
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Institution: | 1. Département de Chimie, Faculté des Sciences, UFA Sétif, Sétif, Algérie;2. Laboratoire de Valorisation des Ressources Naturelles Biologiques, Département de Biologie et Ecologie Végétales, Faculté des Sciences de la Nature et de la Vie, UFA Sétif, Sétif, Algérie;3. EA921 SONAS, SFR4207 QUASAV, UNIV Angers, Université d'Angers, Angers, France;4. Département de Chimie, VARENBIOMOL, Faculté des Sciences Exactes, Université de Constantine 1, Constantine, Algérie https://orcid.org/0000-0002-4999-5673 |
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Abstract: | Alkaloids and phenolic compounds are among the most biologically active natural products from the Jacobaea/Senecio genera (Asteraceae). To isolate original natural products directly from Jacobaea gigantea crude polar extracts, centrifugal partition chromatography (CPC) was used. Previously, we reported the phytochemical study of J. gigantea (syn. Senecio giganteus) n-butanol extract using various classical chromatographical techniques combined with CPC. Herein major constituents from the J. gigantea crude ethyl acetate extract and further compounds from the n-butanol extract were purified in only one step using this technique. A new pyrrolidine alkaloid, named senecipyrrolidine was isolated along with thirteen known compounds – chiro-inositol, three phenolic acids, six flavonoids, two quinones and emiline, another pyrrolidine alkaloid – from crude n-butanol or ethyl acetate extracts. Pyrrolidine alkaloids were isolated for the first time in the Jacobaea/Senecio genera and were probably biogenetically related to the two isolated quinones derivatives jacaranone and 3a-hydroxy-3,3a,7,7a-tetrahydrobenzofuran-2,6-dione, isolated in this species. |
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Keywords: | Centrifugal partition chromatography flavonoids Jacobaea phenolic acids pyrrolidine alkaloids quinones Senecio |
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