A new phenolic glycoside from the Idesia polycarpa Maxim. leaves |
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| Authors: | Lei Huang Tong Peng Yu Li Yunyun He Li Wang Shiyan Zhang |
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| Affiliation: | 1. Institute of New Energy and Low-Carbon Technology, Sichuan University, Chengdu, P.R. China;2. National and Local Joint Engineering Laboratory for Energy Plant Bio-Oil Production and Application, Chengdu, P.R. China;3. National and Local Joint Engineering Laboratory for Energy Plant Bio-Oil Production and Application, Chengdu, P.R. China;4. Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, P.R. China |
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| Abstract: | Phytochemical investigation on the ethyl acetate extract of Idesia polycarpa Maxim. Leaves led to the isolation of four phenolic glycoside isomers (1–4). Compound 2 appeared to be new reported phenolic glycoside, while compound 1 was the first time isolated from the titled species. Their structures were established by IR, UV, HRESI-MS and 1D and 2D NMR spectroscopies analysis and comparison of spectral data with previously reported data. The compounds 3 and 4 showed stronger activity of scavenging the DPPH free radical than the other two compounds, while the compounds 1 and 2 showed a significant activity of scavenging the ABTS free radical. Compounds 2 and 4 exhibited stronger cytotoxicity against HepG2 cell lines compared to compounds 1 and 3. Moreover, compound 3 presented the highest cytotoxicity against MCF cell lines with IC50 value of 37.17?±?0.26?μg/mL than compounds 1, 2 and 4. |
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| Keywords: | Idesia polycarpa Maxim. phenolic glycoside isomers cytotoxicity antioxidant |
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