Daphne striata Tratt. and D. mezereum L.: a study of anti-proliferative activity towards human cancer cells and antioxidant properties |
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Authors: | Rosa Tundis Monica R. Loizzo Marco Bonesi Lorenzo Peruzzi Thomas Efferth |
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Affiliation: | 1. Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Cosenza, Italy;2. Department of Biology, University of Pisa, Pisa, Italy;3. Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany |
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Abstract: | In this study, we investigated for the first time the anti-proliferative and antioxidant properties of D. mezereum and D. striata. The aerial parts were extracted by maceration with n-hexane, dichloromethane, and methanol. MPLC, GC, and GC-MS were used for the phytochemical study. The anti-proliferative activity was tested against MCF-7, A549, LNCaP, ACHN, and C32 cancer human cells. The antioxidant activity was measured by employing β-carotene bleaching, ABTS, DPPH, and FRAP tests. The Relative Antioxidant Capacity Index (RACI) was applied from the perspective of statistics. D. mezereum dichloromethane extract showed a remarkable anti-proliferative with an IC50 of 6.08 μg/mL against LNCaP cells. Experimental data indicate that Daphne species have interesting anti-proliferative and antioxidant properties that deserve more investigations to develop novel antineoplastic drugs. |
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Keywords: | Daphne mezereum D. striata Thymelaeaceae anti-proliferative activity human tumour cells antioxidant activity |
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