Macrocyclic bis-quinolizidine alkaloids from Xestospongia muta |
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| Authors: | Duong Thi Dung Dan Thi Thuy Hang Pham Hai Yen Tran Hong Quang Nguyen Xuan Nhiem Bui Huu Tai |
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| Affiliation: | 1. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam;2. Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam |
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| Abstract: | A new stereoisomer Meso-araguspongine C together with nine reported macrocyclic bis-quinolizidine alkaloids araguspongines A, C, E, L, N?P, petrosin, and petrosin A were isolated from marine sponge Xestospongia muta. Stereochemistry of meso-araguspongine C (2) and araguspongines N-P (3?5) were established by their NMR data and conformational analyses. Both araguspongine C (1) and meso-araguspongine C (2) exhibited great cytotoxic activity towards HepG-2, HL-60, LU-1, MCF-7, and SK-Mel-2 human cancer cells (IC50 in the range of 0.43–1.02 μM). At a concentration of 20 μM, isolated compounds (1?10) also showed modest inhibitory effects (from 7.6 to 40.8%) on the NO production in LPS activated RAW264.7 macrophages. |
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| Keywords: | meso araguspongine C bis quinolizidine alkaloid cytotoxicity Xestospongia muta |
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