Regioselective synthesis of gentisyl alcohol-type marine natural products |
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| Authors: | Hong-Shuang Wang Long-Fei Wang Zhi-Lun Shen |
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| Affiliation: | School of Marine Science and Technology, Harbin Institute of Technology , Weihai, P. R. China |
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| Abstract: | Gentisyl alcohol-type natural products, possessing various important biological properties, have been synthesized from 4-methoxyphenol by using a selective phenol monohydroxymethylation/monochlorination, a CAN oxidation and a sodium dithionite reduction as the key steps. The natural product synthesis is efficient, atom- and step-economical, and requires no protecting groups. |
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| Keywords: | Natural products synthesis gentisyl alcohol chlorogentisyl alcohol hydroxymethylation chlorination |
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