Antifungal activity of Annona coriacea Mart. ethanol extracts against the aetiological agents of cryptococcosis |
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| Authors: | Adriana Araújo de Almeida-Apolonio Fabiana Gomes da Silva Dantas Allan Belarmino Rodrigues Claudia Andréa Lima Cardoso Melyssa Negri Kelly Mari Pires de Oliveira |
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| Institution: | 1. Faculdade de Medicina, Universidade Federal de Mato Grosso do Sul, Campo Grande, Brazil;2. Faculdade de Ciências da Saúde, Universidade Federal da Grande Dourados, Dourados, Brazil;3. Faculdade de Ciências Exatas e Tecnologia, Universidade Federal da Grande Dourados, Dourados, Brazil;4. Departamento de Química, Universidade Estadual de Mato Grosso do Sul, Dourados, Brazil.;5. Departamento de Análise Clínicas, Universidade Estadual de Maringá, Maringá, Brazil;6. Faculdade de Ciências Biológicas e Ambientais, Universidade Federal da Grande Dourados, Dourados, Brazil |
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| Abstract: | Cryptococcosis is an opportunistic disease with a worldwide distribution. This disease is caused by fungi of the genus Cryptococcus, and its treatment is limited to several antifungals. In this study, the antifungal, cytotoxic and mutagenic properties of ethanol extracts from the bark and leaves of Annona coriacea were evaluated against the standard Cryptococcus species and clinical yeast specimens. Both extracts of A. coriacea showed inhibitory activity of 1.5 mg/mL for all of the yeasts tested. The number of viable cells at the lowest tested concentration was 0.187 mg/mL. The extracts that were tested showed inhibitory activity and reduced the fungal growth of the Cryptococcus gattii species and Cryptococcus neoformans species complexes, suggesting that this plant may be an effective alternative treatment for cryptococcosis. |
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| Keywords: | Cryptococcus neoformans Cryptococcus gattii medicinal plant antifungal activity |
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