A novel dimeric flavonol glycoside from Cynanchum acutum subsp. sibiricum |
| |
Authors: | Si-Wen Yuan Wei Dai Xin-Hui Pan Yan Lu |
| |
Affiliation: | 1. Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, School of Pharmacy, Ministry of Education, Shihezi University , Shihezi, P.R. China;2. School of Pharmacy, Department of Pharmacognosy, Fudan University , Shanghai, P.R. China |
| |
Abstract: | A novel dimeric flavonol glycoside, Cynanflavoside A (1), together with six analogues, kaempferol-3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside (2), quercetin-3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside (3), kaempferol-3-O-α-L-rhamnopyranosyl-(1→2)-β-D-xylopyranoside (4), quercetin-3-O-α-L-rhamnopyranosyl-(1→2)-β-D-xylopyranoside (5), kaempferol-3-O-β-D-glucopyranosyl-7-O-α-L-rhamnopyranoside (6), and quercetin-3-O-galactoside (7) were isolated from the n-butyl alcohol extract of Cynanchum acutum subsp. sibiricum. Their structures were determined spectroscopically and compared with previously reported spectral data. All compounds were evaluated for their anti-complementary activity in vitro, and only compound 5 exhibited anti-complement effects with CH50 value of 0.33 mM. |
| |
Keywords: | Asclepiadaceae Cynanchum acutum subsp. sibiricum dimeric flavonol glycoside anti-complementary activity |
|
|