Cytotoxic constituents from Vicia monantha subsp. monantha seeds |
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Authors: | Ali M. El-Halawany Samir M. Osman |
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Affiliation: | 1. Faculty of Pharmacy, Department of Pharmacognosy, Cairo University, Cairo, Egypt;2. Faculty of Pharmacy, Department of Pharmacognosy, October 6 University, Cairo, Egypt |
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Abstract: | Chemical investigation of Vicia monantha subsp. monantha Retz. revealed isolation of one new hydroxy- fatty acid (6) identified as (6-Z, 10-E)-9-hydroxy henicosa-6,10-dienoic acid in addition to six known metabolites; hexadecanoic acid (1), β-sitosterol (2), β-amyrin (3), β-sitosterol-glucoside (4), 2,3-dihydroxypropyl tetradecanoate (5) and (Z)-9-hydroxypentadec-6-enoic acid (7). The cytotoxic effect of the isolated compounds was assessed by MTT assay using lung cancer A-549, prostate cancer PC3, breast cancer MCF-7, colon cancer HCT-116 and liver cancer HepG2 cell lines. Only compounds 1, 2, and 4 showed cytotoxic effect on HCT-116 cells where compound 2 was the most active with IC50 value of 22.61 μg/mL. In addition, compounds 1, 2, 3, and 4 showed promising cytotoxic effect on MCF-7 cells with IC50 values of 21.03, 15.42, 10.089, and 11.34 μg/mL, respectively. |
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Keywords: | Anticancer Vicia monantha subsp. monantha colon cancer breast cancer |
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