Two new triterpenoids from Gardenia jasminoides fruits |
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| Authors: | Dan Lu Weiyang Zhang Yingnan Jiang Yu Zhang Dabo Pan Dan Zhang |
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| Affiliation: | 1. Institute of Traditional Chinese Medicine &2. Natural Products, College of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drug Research, Jinan University, Guangzhou, People’s Republic of China;3. Faculty of Chinese Medicine, Macau University of Science and Technology and State Key Laboratory of Quality Research in Chinese Medicine, Taipa, Macau, People’s Republic of China;4. College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China;5. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China |
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| Abstract: | A new cycloartane triterpenoid, named gardenolic acid C (1), a new ursane triterpenoid, named 3β,16β,21β,23,24-pentahydroxy urs-12,18,20-trien-28-oic acid γ-lactone (2), together with three know triterpenoids, gardenolic acid A (3), gardenolic acid B (4), and 3α,16β,23,24-tetrahydroxy-28-nor-ursane-12,17,19,21-tetraen (5) were isolated from the fruits of Gardenia jasminoides Ellis. The structures of these compounds were elucidated by analyses of spectroscopic data. All isolates were evaluated for their neuroprotective effects in vitro. 
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| Keywords: | Gardeniae Fructus gardenolic acid C ursane-type triterpenoid neuroprotective effect |
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