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An indole diterpenoid isolated from the fungus Drechmeria sp. and its antimicrobial activity
Authors:Jia-Hao Liang  Xiao-Kui Huo  Zhong-Bin Cheng  Jian-Chao Zhao  Xiao-Hui Kang
Affiliation:1. College of Pharmacy, College (Institute) of Integrative Medicine, The National &2. Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease, Dalian Medical University, Dalian, China;3. School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China;4. Pharmaceutical College, Henan University, Kaifeng, China;5. School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China
Abstract:One new indole diterpenoid, drechmerin I (1), was isolated from the fermentation broth of Drechmeria sp. isolated from the root of Panax notoginseng. Its structure was elucidated based on 1 D and 2 D nuclear magnetic resonance (NMR), high resolution electrospray ionization mass spectrum (HRESIMS), and electronic circular dichroism (ECD) spectroscopic analyses as well as TD DFT calculations of ECD spectra. Drechmerin I (1) was assayed for its antimicrobial activity against Candida albicans, Staphylococcus aureus, Bacillus cereus, B. subtillis, Pseudomonas aeruginosa, and Klebsiella pneumonia, respectively. Drechmerin I (1) showed antimicrobial activities against B. subtillis with an MIC value of 200 μg/mL. The interaction of S. aureus peptide deformylase with drechmerin I (1) was investigated by molecular docking.
Keywords:Drechmeria sp.  indole diterpenoid  antimicrobial activity  molecular docking
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