The absolute configuration of anti-Vibrio citrinin dimeric derivative by VCD,ECD and NMR methods |
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| Authors: | Fei Cao Tian-Tian Sun Jian-Kun Yang Guo-Zheng Zhao Qing-Ai Liu Lian-Dong Hu |
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| Affiliation: | 1. Key Laboratory of Medicinal Chemistry and Molecular Diagnostics of Education Ministry of China, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences, Hebei University, Baoding, People’s Republic of China;2. caofei542927001@163.com zhuhuajie@hotmail.com;3. Shandong Provincial Key Laboratory for Biosensors, Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China |
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| Abstract: | ![]()
Citrinin dimeric derivatives are bioactive polyketides previously reported from Penicillium, Aspergillus and Monascus fungi species. Due to the large distance between the stereogenic centers of the two monomer units, it was difficult to determine the absolute configuration of the whole molecule (1). In previous work, the absolute configuration of 1 was just proposed by biogenetic considerations. To address this problem, the experimental VCD of 1 was compared with the corresponding DFT calculations for two diastereomers (1a and 1b). Also, the experimental ECD and NMR spectra of 1 were combined for analysis with the corresponding theoretical predictions for different diastereomers. Additionally, compound 1 showed promising anti-Vibrio activity against pathogenic Vibrio spp. with MIC values ranging from 0.4 to 0.8?μM. | |
| Keywords: | Citrinin dimer absolute configuration vibrational circular dichroism anti-Vibrio activity |
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