Phenolic composition,antioxidant and antinociceptive activities of Syringa vulgaris L. bark and leaf extracts |
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| Authors: | Erzsébet Varga Csenge Barabás Anita Tóth Imre Boldizsár Béla Noszál |
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| Institution: | 1. Department of Pharmacognosy and Phytotherapy, University of Medicine and Pharmacy, Targu Mure?, Romania;2. Department of Pharmacognosy, Semmelweis University, Budapest, Hungary;3. Department of Plant Anatomy, Institute of Biology, L. E?tv?s University, Budapest, Hungary;4. Department of Pharmaceutical Chemistry, Semmelweis University, Budapest, Hungary |
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| Abstract: | Metabolite profile, antioxidant and antinociceptive activities of Syringa vulgaris bark and leaf methanolic extracts were investigated. By means of HPLC-DAD-ESI-TOF and HPLC-DAD-ESI-MS/MS, a total of 33 phenolics were identified, including 15 secoiridoids, 6 phenylpropanoids, 3 flavonoids, 3 lignans and 6 low molecular weight phenols. Validated quantitative analysis show that syringin (2.52%) and rutin (1.13%) are the main phenolic compounds in bark and leaf, respectively. Notable radical scavenging and antinociceptive activities of the bark and leaf extracts were confirmed by in vitro DPPH● and ABTS●+ assays and by in vivo hot-plate method in mice, respectively. Our results could lay the scientific basic of future clinical perspectives of lilac bark and leaf. |
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| Keywords: | Phenolic profiling Syringa vulgaris oleuropein antioxidant activity antinociceptive activity |
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