A new morphinandienone alkaloid from the stems of Fissistigma tungfangense |
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| Authors: | Qi Zhou Yan-Hui Fu Yu-Qin Zhang Shou-Yuan Wu Xiao-Ping Song |
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| Institution: | 1. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China;2. College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P. R. China;3. College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P. R. China |
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| Abstract: | A new morphinandienone alkaloid, fissistigmine A (1), together with three known alkaloids (2?4), were isolated and identified from the stems of Fissistigma tungfangense. Among them, fissistigmine A (1) represents the first example of a novel naturally occurring morphinandienone alkaloid with a unique cleavage of the C-9?N-17 bond. All isolated compounds were evaluated for their anti-rheumatoid arthritis activities via examining their anti-proliferative effects on synoviocytes in vitro. Compound 1 exhibited inhibitory effect on the proliferation of synoviocytes with an IC50 value of 114.6 ± 2.2 μM. |
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| Keywords: | Fissistigma tungfangense morphinandienone alkaloid fissistigmine A anti-rheumatoid arthritis anti-proliferative effect on synoviocytes |
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