Polygonatone H,a new homoisoflavanone with cytotoxicity from Polygonatum Cyrtonema Hua. |
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| Authors: | Wenxiang Wang Xilatu Dabu Juan He Huixiang Yang Shengchao Yang Junwen Chen |
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| Institution: | 1. Yunnan Agricultural University National &2. Local Joint Engineering Research Center on Gemplasm Utilization &3. Innovation of Chinese Medicinal Materials in Southwest China, Kunming, China;4. College of Resources and Environment, Yunnan Agricultural University, Kunming, China;5. School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China |
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| Abstract: | A new homoisoflavonoid, (3R)-5,7-dihydroxy-6-methyl-3-(2′-hydroxy-4′-methoxybenzyl)-chroman-4-one (1), namely polygonatone H, in addition to fourteen known homoisoflavones (2–15) were isolated from the rhizome of Polygonatum Cyrtonema Hua. The structures were identified with the aid of 1D/2D NMR spectroscopic technologies. Compounds 2, 6, 8, 10, 11, 13, and 15 were isolated from P. Cyrtonema for the first time. Compound 1 showed cytotoxicities to human cancer cell lines with IC50 values to comparable those of cisplatin. |
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| Keywords: | Polygonatum cyrtonema Hua homoisoflavone cytotoxicity |
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