New pharmacological insights of Galactia glaucescens |
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| Authors: | Márcio G dos Santos Felipe S Moreno Akila L de Oliveira Isadora C F Oliveira Natália Tribuiani José C Cogo |
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| Institution: | 1. Environmental Sciences Post-Graduate Program (PGCiamb), Tocantins Federal University (UFT), Palmas, Brazil;2. Veterinary Medicine Graduate Course, University of Sorocaba (UNISO), Sorocaba, Brazil;3. Faculty of Pharmaceutical Sciences, University of Campinas (UNICAMP), Campinas, Brazil;4. Post-Graduate Program in Pharmaceutical Sciences, University of Sorocaba (UNISO), Sorocaba, Brazil;5. Biomedical Engineering and Bioengineering, University Brasil, S?o Paulo, Brazil |
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| Abstract: | Galactia glaucescens leaves are popularly used against snakebites in Brazil. The hydroethanolic extract from aerial parts of G. glaucescens (HEGg) was assayed against the neurotoxicity and myotoxicity induced by Bothrops jararacussu venom. A traditional myographic technique was applied for neurotoxicity and the resulting muscles were treated routinely by light microscopy analysis for myotoxicity. Additionally, the antimicrobial potential of HEGg was evaluated against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa strains, as well as Rutin was isolated for the first time in this specie using chromatographic and spectroscopic methods and its antiophidian property was assessed. HEGg totally prevents the neurotoxicity and myotoxicity effects caused by B. jararacussu, but did not show any antimicrobial effect. Concluding, HEGg and Rutin were able to counteract the toxic effects of the venom and confirmed the antiophidian potential, but not antimicrobial, of G. glaucescens as an alternative for neutralization of B. jararacussu venom. |
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| Keywords: | Antimicrobial antiophidian Galactia glaucescens leaves 3-foliolate neglected tropical disease Rutin |
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