Efficient one-pot catalyst-free synthesis of novel coumarin- spiro[indoline-3,4'-pyran] conjugates via three-component domino reaction in aqueous medium |
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| Authors: | Adil Omar |
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| Affiliation: | 1. Key Laboratory of Oil &2. Gas Fine Chemicals, Ministry of Education &3. Xinjiang Uyghur Autonomous Region, College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi, PR People's Republic of China |
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| Abstract: | A simple, efficient, eco-friendly and catalyst-free procedure was developed for the construction of novel coumarin-spiro[indoline-3,4'-pyran] conjugates via three-component reactions of various synthetic beta-ketoesters with isatins and malononitrile in aqueous medium. In addition to operational simplicity and absence of tedious separation procedures, being catalyst–free is the prominent advantage of this method. |
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| Keywords: | Coumarins spiro-indoline pyran one-pot synthesis catalyst-free |
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