Synthesis of dihydroisorcordoin derivatives and their in vitro anti-oomycete activities |
| |
Authors: | Iván Montenegro |
| |
Institution: | Escuela de Obstetricia y Puericultura, Facultad de medicina, Campus de la Salud, Universidad de Valparaíso , Vi?a del Mar, Chile |
| |
Abstract: | A series of novel dihydrochalcone derivatives 2–7 were synthesized from dihydroisorcordoin 1 which was isolated from the aerial parts of Adesmia balsamica. The structures of all compounds were confirmed by 1H NMR, 13C NMR, and HRMS. Their anti-oomycete activity was evaluated in vitro against Saprolegnia parasitica and Saprolegnia diclina. Some of the newly synthesized compounds exhibited better anti-oomycete activities at low values compared with bronopol and fluconazole as positive controls. Among them, compound 7 exhibited strong activity, with minimum inhibitory concentration and minimum oomyceticidal concentration values of 75 and 100 μg/mL, respectively. |
| |
Keywords: | Adesmia balsamica dihydroisorcordoin anti-oomycete activity Saprolegnia sp |
|
|