Effect of Anacardium occidentale leaf extract on human acute lymphoblastic leukaemia cell lines |
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| Authors: | Janaína M. Santos Nathalia M. Cury José A. Yunes Jorge A. López |
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| Affiliation: | 1. Programa de Pós-Gradua??o em Biotecnologia Industrial, Universidade Tiradentes/Instituto de Tecnologia e Pesquisa, Aracaju, Brasil;2. Laboratório de Biologia Molecular, Centro Infantil Boldrini, Campinas, Brasil;3. Faculdade de Ciências Médicas, Departamento de Genética Médica, UNICAMP, Campinas, Brasil |
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| Abstract: | Anacardium occidentale leaves are used in folk medicine due its therapeutic properties attributed to phenolic compounds. Therefore, this study was undertaken on its hydroethanolic leaf extract (AoHE) to evaluate cytotoxicity and apoptosis induction on acute lymphoblastic leukaemia cells. Results indicated that AoHE interfered in the cell cycle progression, inducing apoptosis by activation of casp3 at lower concentrations, thence, a promising candidate for the development of new cancer drugs. |
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| Keywords: | Cashew polyphenols apoptosis leukaemia cells |
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