12-Epi-9-deacetoxyxenicin,new cytotoxic diterpenoid from a Bornean soft coral,Xenia sp. |
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| Authors: | Chin-Soon Phan Takashi Kamada Takahiro Ishii Toshiyuki Hamada |
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| Affiliation: | 1. Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah , Kota Kinabalu, Malaysia;2. Faculty of Agriculture, Department of Bioscience and Biotechnology, University of the Ryukyus , Nishihara, Japan;3. Graduate School of Science and Engineering, Kagoshima University , Kagoshima, Japan |
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| Abstract: | One new compound, 12-epi-9-deacetoxyxenicin (1) along with a hydroperoxide product, 12-epi-9-deacetoxy-8-hydroperoxyxenicin (2) and two known sesquiterpenoids (3–4) were isolated from a population of Bornean soft coral Xenia sp. The structures of these secondary metabolites were elucidated based on their spectroscopic data. Compounds 1 and 2 showed cytotoxic activity against ATL cell line, S1T. In addition, compound 3 exhibited hyphal inhibition of Lagenidium thermophilum. |
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| Keywords: | Soft coral Xenia sp. xenicane diterpene adult T-cell leukemia |
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