Monanchoxymycalin C with anticancer properties,new analogue of crambescidin 800 from the marine sponge Monanchora pulchra |
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| Authors: | Larisa Kimovna Shubina Gunhild von Amsberg Vladimir Anatolievich Denisenko Roman Sergeevich Popov Sergey Anatolievich Dyshlovoy |
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| Institution: | 1. Laboratory of Marine Natural Products Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Vladivostok, Russian Federation;2. Laboratory of Experimental Oncology, Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumorzentrum, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;3. Laboratory of Experimental Oncology, Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumorzentrum, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;4. School of Natural Sciences, Far East Federal University, Vladivostok, Russian Federation |
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| Abstract: | A new pentacyclic guanidine alkaloid, monanchoxymycalin C (1) was isolated from a new collection of marine sponge Monanchora pulchra along with the known monanchoxymycalin A (2). The structure of 1 was elucidated on the basis of spectroscopic data. Monanchoxymycalin C exhibits cytotoxic activity against human cancer HeLa cells at low micromolar concentrations, induces apoptosis-related death of malignant cells and inhibits cancer cell colony formation. In addition, synergistic and additive effects have been observed in combination with cisplatin. |
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| Keywords: | Pentacyclic guanidine alkaloids marine sponge cytotoxic activity apoptosis |
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