The polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activity |
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| Authors: | Boris Pejin Kristina Te?anovi? Dragica Jakovljevi? Sonja Kai?arevi? Filip ?ibul Milena Ra?eta |
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| Institution: | 1. Department of Life Sciences, Institute for Multidisciplinary Research – IMSI, University of Belgrade, Belgrade, Serbiabrspjn@gmail.com borispejin@imsi.rs;2. Faculty of Sciences, Department of Biology and Ecology, University of Novi Sad, Novi Sad, Serbia;3. Department of Chemistry, Institute of Chemistry, Technology and Metallurgy – ICTM, University of Belgrade, Belgrade, Serbia;4. Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection, University of Novi Sad, Novi Sad, Serbia |
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| Abstract: | The polysaccharide (PSH) extracts from the edible mushroom species Coprinus comatus and Coprinellus truncorum were screened in liquid for their acetylcholinesterase inhibitory (AChE) activity. Both extracts were found to display inhibition of the aforementioned enzyme reaching similar IC50 values of 0.62 ± 0.07 and 0.61 ± 0.03 mg/mL, respectively. According to the means of FTIR spectroscopy, these PSH extracts mostly contained β-glucans. However, the presence of some proteins and polyphenolics as minor ingredients were also detected. Compared with existing literature data for anti-AChE activity of the sugar samples, the findings within this study may be treated as a profound bioactivity. Consequently, this study puts some light on the possible use of the screened macrofungi in the palliative treatment of Alzheimer’s disease. |
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| Keywords: | Mushrooms sugars AChE inhibitors of natural origin not belonging to the alkaloids Alzheimer’s disease |
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