A new cadinane sesquiterpenoid glucoside with cytotoxicity from Abelmoschus sagittifolius |
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| Authors: | De-Li Chen Guang Li Yang-Yang Liu Guo-Xu Ma Wei Zheng Xiao-Bo Sun |
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| Institution: | 1. Hainan Branch Institute of Medicinal Plant Development (Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine), Chinese Academy of Medical Sciences &2. Peking Union Medical College, Wanning, China;3. Yunnan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences &4. Peking Union Medical College, Xishuangbanna, China;5. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences &6. Peking Union Medical College, Beijing, China;7. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & |
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| Abstract: | A new cadinane sesquiterpenoid glucoside, 2β,7,3-trihydroxycalamenene 3-O-β-d-glucoside (1) together with six known compounds, N-(p-trans-coumaroyl)-N-methyl tyramine (2), Cleomiscosin A (3), 9,12,13-trihydroxy-10,15-heptadecadienoic acid (4), Cytochalasin B (5), Marmesinin (6) and N-(p-trans-coumaroyl) tyramine (7) were obtained from the stem bark of Abelmoschus sagittifolius. The new structure of compound 1 was elucidated by analysing its 1H and 13C-NMR, 1H-1H COSY, HSQC, HMBC, NOESY and HR-ESI-MS spectra. Compounds 1–7 showed moderate cytotoxicity against Hela and HepG-2 human cancer cell lines. |
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| Keywords: | Abelmoschus sagittifolius sesquiterpenoid cytotoxicity |
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