| 采用核磁共振/液相色谱-质谱异相关谱方法开展药用植物草棉活性提取物中多组分的同步结构分析研究 |
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| 引用本文： | 代冬梅,贺玖明,刘超,孙瑞祥,张瑞萍,阿吉艾克拜尔·艾萨,再帕尔·阿不力孜. 采用核磁共振/液相色谱-质谱异相关谱方法开展药用植物草棉活性提取物中多组分的同步结构分析研究[J]. 分析化学, 2011, 39(6): 781-787. DOI: 10.3724/SP.J.1096.2011.00781 |
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| 作者姓名： | 代冬梅 贺玖明 刘超 孙瑞祥 张瑞萍 阿吉艾克拜尔·艾萨 再帕尔·阿不力孜 |
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| 作者单位： | 代冬梅,DAI Dong-Mei(浙江大学宁波理工学院,分子设计和营养工程重点实验室,宁波,315100;中国医学科学院/北京协和医学院,药物研究所,中草药物质基础与资源利用教育部重点实验室,北京,100050);贺玖明,张瑞萍,再帕尔·阿不力孜,HE Jiu-Ming,ZHANG Rui-Ping,Zeper ABLIZ(中国医学科学院/北京协和医学院,药物研究所,中草药物质基础与资源利用教育部重点实验室,北京,100050);刘超,孙瑞祥,LIU Chao,SUN Rui-Xiang(中国科学院计算技术研究所,北京,100080);阿吉艾克拜尔·艾萨,Haji Akber AISA(中国科学院新疆理化技术研究所,乌鲁木齐,830011) |
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| 摘 要： | 基于不完全分离分析策略,建立了NMR/LC-MS异相关谱(NMR/LC-MS HCS)方法对系列混合物样品的LC-MS和NMR谱数据的整合分析,发掘混合物图谱中来自同一组分的LC-MS和NMR谱数据间的内在相关性.以新疆维吾尔民族药用植物草棉(Gossypium herbaceam L.)花瓣的乙醇提取物(AB-8-2...
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| 关 键 词： | 核磁共振/液相色谱-质谱异相关谱 混合物不完全分离 多组分同步结构鉴定 草棉植物 黄酮苷类 |
Simultaneous Structural Identification of Constituents in Active Herbal Extract of Gossypium Herbaceam Using Nuclear Magnetic Resonance/Liquid Chromatography-Mass Spectrometry Hetero-Correlation Spectroscopy |
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| DAI Dong-Mei,HE Jiu-Ming,LIU Chao,SUN Rui-Xiang,ZHANG Rui-Ping,Haji Akber AISA,Zeper ABLIZ. Simultaneous Structural Identification of Constituents in Active Herbal Extract of Gossypium Herbaceam Using Nuclear Magnetic Resonance/Liquid Chromatography-Mass Spectrometry Hetero-Correlation Spectroscopy[J]. Chinese Journal of Analytical Chemistry, 2011, 39(6): 781-787. DOI: 10.3724/SP.J.1096.2011.00781 |
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| Authors: | DAI Dong-Mei HE Jiu-Ming LIU Chao SUN Rui-Xiang ZHANG Rui-Ping Haji Akber AISA Zeper ABLIZ |
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| Affiliation: | DAI Dong-Mei1,2,HE Jiu-Ming2,LIU Chao3,SUN Rui-Xiang3,ZHANG Rui-Ping2,Haji Akber AISA4,Zeper ABLIZ2 1(Key Laboratory for Molecular Design and Nutrition Engineering,Ningbo Institute of Technology,Zhejiang University,Ningbo 315104) 2(Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine,Ministry of Education,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050) 3(Institute of Computing Technology,Chinese Academy... |
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| Abstract: | To simplify and accelerate the analytical routes for structure identification of constituents in complex mixture,based on an incomplete separation strategy,MS/NMR hetero-correlation spectroscopy(MS/NMR-HCS) was developed as a new analytical method to discover the intrinsic correlation between LC-MS and NMR data of the same constituent from mixture spectra.The ethanol crude extract of the petals of Gossypium herbaceam was separated into a series of fractions with the concentration of constituent dynamic vari... |
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| Keywords: | Nuclear magnetic resonance/liquid chromatography-mass spectrometry hetero-correlation spectroscopy Incomplete separation strategy Simultaneous structural identification in mixture Gossypium herbaceam Flavonol glycosides |
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