| 基于二元混合自组装包裹纳米颗粒的微传感器抗体固定方法 |
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| 引用本文： | 薛茜男,边超,佟建华,孙楫舟,张虹,夏善红.基于二元混合自组装包裹纳米颗粒的微传感器抗体固定方法[J].分析化学,2011,39(6):804-808. |
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| 作者姓名： | 薛茜男 边超 佟建华 孙楫舟 张虹 夏善红 |
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| 作者单位： | 薛茜男,XUE Qian-Nan(中国科学院电子学研究所传感技术联合国家重点实验室北方基地,北京,100190;中国科学院研究生院,北京,100080);边超,佟建华,孙楫舟,张虹,夏善红,BIAN Chao,TONG Jian-Hua,SUN Ji-Zhou,ZHANG Hong,XIA Shan-Hong(中国科学院电子学研究所传感技术联合国家重点实验室北方基地,北京,100190) |
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| 基金项目： | 国家973计划项目，国家863计划项目 |
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| 摘 要： | 采用二元混合自组装膜修饰纳米金颗粒,在经自组装单分子层修饰的金电极上阵列式排布,并通过共价键固定抗体形成生物敏感膜.采用原子力显微镜、扫描电镜和阻抗谱分别对电极表面的修饰过程进行了表征.纳米粒子在微电极表面均匀分布,没有明显的团聚,并且可实现抗体有效固定.基于标准互补金属氧化物半导体(Complementary met...
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| 关 键 词： | 纳米金 互补金属氧化物半导体 微加工 糖化血红蛋白 集成芯片 |
Micro Biosensor Antibody Immobilization Method Based on Mixed Self-assembly-monolayers Wrapped Nano-particle |
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| XUE Qian-Nan,BIAN Chao,TONG Jian-Hua,SUN Ji-Zhou,ZHANG Hong,XIA Shan-Hong.Micro Biosensor Antibody Immobilization Method Based on Mixed Self-assembly-monolayers Wrapped Nano-particle[J].Chinese Journal of Analytical Chemistry,2011,39(6):804-808. |
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| Authors: | XUE Qian-Nan BIAN Chao TONG Jian-Hua SUN Ji-Zhou ZHANG Hong XIA Shan-Hong |
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| Institution: | XUE Qian-Nan1,2,BIAN Chao1,TONG Jian-Hua1,SUN Ji-Zhou1,ZHANG Hong1,XIA Shan-Hong1 1(State Key Laboratory of Transducer Technology Institute of Electronics,Chinese Academy of Sciences,Beijing 100190) 2(Graduate University of Chinese Academy of Sciences,Beijing 100080) |
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| Abstract: | Nano-gold particles that wrapped by mixed self-assembly monolayers(SAM) were immobilized on the SAM-modified Au micro electrode surface by amide linkage to form nano-particles array.Subsequently,a sensitive bio-film on the micro immunosensor surface was formed with covalent immobilization of antibodies on the nano-particles.Micro electrode surface modification process was characterized by atomic force microscopy, scanning electron microscope,and electrochemical impe-dance spectroscopy.The results indicated ... |
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| Keywords: | Nano-gold Metal-oxide semiconductor Micro-electronic mechanical system Hemoglobin-A1c Integrated chip |
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