Synthesis of derivatives of pyrrolo[1, 2-α]pyrmidine |
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Authors: | V I Shvedov I A Kharizomenova L B Altukhova A N Grinvev |
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Institution: | 1. Ordzhonikidze All-Union Scientific-Research Chemical and Pharmaceutical Institute, Moscow
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Abstract: | Continuing investigations in the field of the synthesis of condensed heterocyclic systems containing pyrrole and indole fragments ¦1–3¦, we have condensed of 2-aminopyrrole derivatives with various 1, 3-dicarbonyl compounds. The reaction took place at the boil in solutions in pyridine or acetic acid, and also without a solvent at 150–160° C, forming in a single stage derivatives of pyrrolo1, 2-a]pyrimidine (I–III) and pyrrolo2, 1-b]-tetrahydroquinazoline (IV–VI). The condensation of 2-aminopyrrole with acetoacetic and substituted acetoacetic esters led to 4-oxo derivatives of pyrrolo1, 2-β]pyrimidine (VII and VIII). |
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