Rapid extraction of codeine and morphine in whole blood for HPLC analysis |
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| Authors: | I R Tebbett |
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| Institution: | (1) Forensic Science Unit, University of Strathclyde, Royal College, 204 George Street, G1 1XW Glasgow, UK |
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| Abstract: | Summary A rapid and efficient procedure is described for the extraction and analysis of codeine and morphine in whole blood. Red blood
cells were fragmented by sonication and the blood sample extracted by passing through a bonded silica column (Bond Elute?). The adsorbed drugs were washed and eluted followed by analysis by HPLC. Recoveries were between 95–100% at 5 ng/ml concentrations. |
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| Keywords: | Column liquid chromatography Solid phase extraction Codeine and morphine in blood |
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