Biosynthetic Conclusions from the Functional Dissection of Oxygenases for Biosynthesis of Actinorhodin and Related Streptomyces Antibiotics期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Biosynthetic Conclusions from the Functional Dissection of Oxygenases for Biosynthesis of Actinorhodin and Related Streptomyces Antibiotics

Authors:	Takaaki Taguchi Masaki Yabe Hitomi Odaki Miki Shinozaki Mikko Metsä-Ketelä Takao Arai Susumu Okamoto Koji Ichinose

Affiliation:	1. Research Institute of Pharmaceutical Sciences, Musashino University, Shinmachi, Nishitokyo-shi, Tokyo 202-8585, Japan;2. National Food Research Institute, Kannondai, Tsukuba-shi, Ibaraki 305-8642, Japan;3. Department of Biological Science, Tokyo University of Science, Yamazaki, Noda-shi, Chiba 278-8510, Japan;4. Department of Biochemistry and Food Chemistry, University of Turku, FIN-20014 Turku, Finland

Abstract:	Download : Download high-res image (332KB) Download : Download full-size image Highlights? ActVA-ORF5 is a flavin-dependent monooxygenase required for actinorhodin biosynthesis ? ActVA-ORF5 and its three close homologs were functionally dissected ? ActVA-ORF5 and Gra-21 are bifunctional at C-6/C-8, while Med-7 acts only for C-6 ? AlnT exhibits different regiospecificity for oxidation of tricyclic substrates

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