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Deglycosylation as a Mechanism of Inducible Antibiotic Resistance Revealed Using a Global Relational Tree for One-Component Regulators

Authors:	Leslie Cuthbertson,Sang Kyun Ahn,Justin R. Nodwell

Affiliation:	1. Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada;2. M.G. DeGroote Institute for Infectious Disease Research, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada

Abstract:	Download : Download high-res image (98KB) Download : Download full-size image Highlights? Phylogenomics can be used to predict cognate ligands for TetR-family regulators ? KijR (SCO7719) regulates kijX (SCO7720) in response to the antibiotic kijanimicin ? kijX encodes a kijanimicin-resistance determinant ? KijX is a glycosyl hydrolase and inactivates kijanimicin through deglycosylation

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