1. Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada;2. M.G. DeGroote Institute for Infectious Disease Research, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada
Abstract:
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Highlights? Phylogenomics can be used to predict cognate ligands for TetR-family regulators ? KijR (SCO7719) regulates kijX (SCO7720) in response to the antibiotic kijanimicin ? kijX encodes a kijanimicin-resistance determinant ? KijX is a glycosyl hydrolase and inactivates kijanimicin through deglycosylation