1. Department of Chemistry, University of Chicago, Chicago, IL 60637, USA;2. Center for Drug Design, University of Minnesota, Minneapolis, MN 55455, USA
Abstract:
Download : Download high-res image (110KB)
Download : Download full-size image
Highlights? Yeast surface display to engineer substrate recognition of adenylation (A) domains ? Synthesis of bisubstrate inhibitors for yeast selection of A domain library ? Identifying DhbE mutants specific for 3-hydroxybenzoic acid and 2-aminobenzoic acid ? Key residues in A domain for substrate recognition and transfer
