Engineering the Substrate Specificity of the DhbE Adenylation Domain by Yeast Cell Surface Display期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Engineering the Substrate Specificity of the DhbE Adenylation Domain by Yeast Cell Surface Display

Authors:	Keya Zhang Kathryn M Nelson Karan Bhuripanyo Kimberly D Grimes Bo Zhao Courtney C Aldrich Jun Yin

Institution:	1. Department of Chemistry, University of Chicago, Chicago, IL 60637, USA;2. Center for Drug Design, University of Minnesota, Minneapolis, MN 55455, USA

Abstract:	Download : Download high-res image (110KB) Download : Download full-size image Highlights? Yeast surface display to engineer substrate recognition of adenylation (A) domains ? Synthesis of bisubstrate inhibitors for yeast selection of A domain library ? Identifying DhbE mutants specific for 3-hydroxybenzoic acid and 2-aminobenzoic acid ? Key residues in A domain for substrate recognition and transfer

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