Direct reductive amination of aldehydes and ketones using phenylsilane: catalysis by dibutyltin dichloride |
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Authors: | Apodaca R Xiao W |
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Affiliation: | The R.W. Johnson Pharmaceutical Research Institute, San Diego, California 92121, USA. rapodaca@prius.jnj.com |
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Abstract: | A procedure for direct reductive amination of aldehydes and ketones was developed which uses phenylsilane as a stoichiometric reductant and dibutyltin dichloride as a catalyst. Suitable amines included anilines and dialkylamines but not monoalkylamines. |
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