An alternative route for Carboni-Lindsey reaction: N,N cycloaddition of an alkene to s-tetrazine |
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| Authors: | Zhou X Kovalev E G Klug J T Khodorkovsky V |
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| Affiliation: | The Institutes for Applied Research and the Department of Chemistry, Ben-Gurion University of the Negev, POB 653, Beer-Sheva 84105, Israel. |
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| Abstract: | Quantum mechanical calculations show that N,N cycloaddition of alkenes and alkynes to s-tetrazines is possible as an alternative to the well-known C,C cycloaddition (Carboni-Lindsey reaction). Formation of 1,2,4-triazole derivatives (formal product of N,N cycloaddition) along with the pyrazole (formal product of C,C cycloaddition) corroborates this theoretical prediction. |
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