Highly enantioselective hydrogenation of (E)-beta-(acylamino)acrylates catalyzed by Rh(i)-complexes of electron-rich P-chirogenic diphosphines |
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Authors: | Yasutake M Gridnev I D Higashi N Imamoto T |
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Affiliation: | Department of Chemistry, Faculty of Science, Chiba University, Chiba 263-8522, Japan. |
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Abstract: | Excellent enantioselectivities up to 99.7% were achieved in the hydrogenation of (E)-beta-(acylamino)acrylates by the use of Rh(I)-complexes of electron-rich diphosphines, t-Bu-BisP and t-Bu-MiniPHOS. Low-temperature NMR experiments testify that monohydrides with beta-carbon atom of the substrate bound to rhodium are involved in the catalytic cycle. |
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