Regioselective palladium-catalyzed arylation of 2-furaldehyde |
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| Authors: | McClure M S Glover B McSorley E Millar A Osterhout M H Roschangar F |
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| Affiliation: | GlaxoSmithKline, Chemical Development, Five Moore Drive, P.O. Box 13398, Research Triangle Park, North Carolina 27709, USA. msm81971@gsk.com |
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| Abstract: | An efficient regioselective method for the direct arylation of 2-furaldehyde to provide a range of pi-diverse 5-aryl-2-formylfuran derivatives is described. The method employs functionalized aryl halides and a catalytic amount of palladium(II) chloride under relatively mild conditions. |
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